This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology deals with the subject of oxidative processes mediated by copper ions within biological systems. The book addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond forming reactions as well as enantioselective oxidation chemistries. It covers a wide array of reaction types, such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing the O2 molecule, and progresses from biological systems and spectroscopy and related theory to bioinorganic models and applications.

InhaltsangabePreface to Series vii Introduction ix Contributors xi 1 Insights into the Proposed Copper-Oxygen Intermediates that Regulate the Mechanism of Reactions Catalyzed by Dopamine b-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, and Tyramine b-Monooxygenase 1 Robert L. Osborne and Judith P. Klinman 2 Copper Dioxygenases 23 Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier 3 Amine Oxidase and Galactose Oxidase 53 Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M. Dooley 4 Energy Conversion and Conservation by Cytochrome Oxidases 107 Angela Paulus and Simon de Vries 5 Multicopper Proteins 131 Takeshi Sakurai and Kunishige Kataoka 6 Structure and Reactivity of Copper-Oxygen Species Revealed by Competitive Oxygen-18 Isotope Effects 169 Justine P. Roth 7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes 197 Kazunari Yoshizawa 8 Chemical Reactivity of Copper Active-Oxygen Complexes 225 Shinobu Itoh 9 Cytochrome c Oxidase and Models 283 Zakaria Halime and Kenneth D. Karlin 10 Supramolecular Copper Dioxygen Chemistry 321 JeanNoel Rebilly and Olivia Reinaud 11 Organic Synthetic Methods Using Copper Oxygen Chemistry 361 Marisa C. Kozlowski Index 445

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